Mathematical Model of ATM Activation and Chromatin Relaxation by Ionizing Radiation.

ABSTRACT: We propose a comprehensive mathematical model to study the dynamics of ionizing radiation induced Ataxia-telangiectasia mutated (ATM) activation that consists of ATM activation through dual mechanisms: the initiative activation pathway triggered by the DNA damage-induced local chromatin relaxation and the primary activation pathway consisting of a self-activation loop by interplay with chromatin relaxation. The model is expressed as a series of biochemical reactions, governed by a system of differential equations and analyzed by dynamical systems techniques. Radiation induced double strand breaks (DSBs) cause rapid local chromatin relaxation, which is independent of ATM but initiates ATM activation at damage sites. Key to the model description is how chromatin relaxation follows when activ

SUBMITTER: Li Y 

PROVIDER: S-EPMC7072770 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature