Induction of a Specific Humoral Immune Response by Nasal Delivery of Bcla2_ctd of Clostridioides difficile.

ABSTRACT: Clostridioides difficile, formerly known as Clostridium difficile, is a spore-forming bacterium considered as the most common cause of nosocomial infections in developed countries. The spore of C. difficile is involved in the transmission of the pathogen and in its first interaction with the host; therefore, a therapeutic approach able to control C. difficile spores would improve the clearance of the infection. The C-terminal (CTD) end of BclA2, a spore surface protein of C. difficile responsible of the interaction with the host intestinal cells, was selected as a putative mucosal antigen. The BclA2 fragment, BclA2_CTD, was purified and used to nasally immunize mice both as a free protein and after adsorption to the spore of Bacillus subtilis

SUBMITTER: Maia AR 

PROVIDER: S-EPMC7072882 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature