P53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality?

ABSTRACT: Identification of p73 as a structural homolog of p53 fueled early studies aimed at determining if it was capable of performing p53-like functions. This led to a conundrum as p73 was discovered to be hardly mutated in cancers, and yet, TAp73, the full-length form, was found capable of performing p53-like functions, including transactivation of many p53 target genes in cancer cell lines. Generation of mice lacking p73/TAp73 revealed a plethora of developmental defects, with very limited spontaneous tumors arising only at a later stage. Concurrently, novel TAp73 target genes involved in cellular growth promotion that are not regulated by p53 were identified, mooting the possibility that TAp73 may have diametrically opposite functions to p53 in tumorigenesis. We have therefore comprehen

SUBMITTER: Wang C 

PROVIDER: S-EPMC7072922 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature