Zinc Finger Proteins in the Human Fungal Pathogen Cryptococcus neoformans.

ABSTRACT: Zinc is one of the essential trace elements in eukaryotes and it is a critical structural component of a large number of proteins. Zinc finger proteins (ZNFs) are zinc-finger domain-containing proteins stabilized by bound zinc ions and they form the most abundant proteins, serving extraordinarily diverse biological functions. In recent years, many ZNFs have been identified and characterized in the human fungal pathogen Cryptococcus neoformans, a fungal pathogen causing fatal meningitis mainly in immunocompromised individuals. It has been shown that ZNFs play important roles in the morphological development, differentiation, and virulence of C. neoformans. In this review, we, first, briefly introduce the ZNFs and their classification. Then, we explain the identification and cl

SUBMITTER: Li YH 

PROVIDER: S-EPMC7072944 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature