LDAI-ISPS: LncRNA-Disease Associations Inference Based on Integrated Space Projection Scores.

ABSTRACT: Long non-coding RNAs (long ncRNAs, lncRNAs) of all kinds have been implicated in a range of cell developmental processes and diseases, while they are not translated into proteins. Inferring diseases associated lncRNAs by computational methods can be helpful to understand the pathogenesis of diseases, but those current computational methods still have not achieved remarkable predictive performance: such as the inaccurate construction of similarity networks and inadequate numbers of known lncRNA-disease associations. In this research, we proposed a lncRNA-disease associations inference based on integrated space projection scores (LDAI-ISPS) composed of the following key steps: changing the Boolean network of known lncRNA-disease associations into the weighted networks via combining all the g

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC7073162 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature