In vitro anticancer activity of methanolic extract of Granulocystopsis sp., a microalgae from an oligotrophic oasis in the Chihuahuan desert.

ABSTRACT: With the purpose of discovering new anticancer molecules that might have fewer side effects or reduce resistance to current antitumor drugs, a bioprospecting study of the microalgae of the Cuatro Cienegas Basin (CCB), an oasis in the Chihuahuan desert in Mexico was conducted. A microalgae was identified as Granulocystopsis sp. through sequencing the rbcL gene and reconstruction of a phylogenetic tree, and its anticancer activities were assessed using various in vitro assays and different cell lines of human cancers, including lung, skin melanoma, colorectal, breast and prostatic cancers, as well as a normal cell line. The values of IC₅₀ of the microalgae methanolic extract using the MTT assay were lower than 20 μg/ml, except that in the lung cancer line and the nor

SUBMITTER: Tavares-Carreon F 

PROVIDER: S-EPMC7073244 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature