Paediatric haemodynamic modelling: development and experimental validation using quantitative flow MRI.

ABSTRACT:

Background

Congenital vascular disease is one of the leading causes of death in paediatric age. Despite the importance of paediatric haemodynamics, large investigations have been devoted to the evaluation of circulation in adults. The novelty of this study consists in the development of a well calibrated mathematical model of cardiovascular circulation in paediatric subjects. To reach the purpose, a model for adult circulation was modified and recalibrated with experimental data and literature from children to be able to calculate the flow rates and pressures in the brain and neck.

Methods

The haemodynamic model simulates the 76 main arteries, together with the main veins in brain and neck. A proper magnetic resonance imaging (MRI) dataset of 29 volunteers aged 12 ± 5 years

SUBMITTER: Mohammadyari P 

PROVIDER: S-EPMC7073351 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature