The Bacillus Subtilis K-State Promotes Stationary-Phase Mutagenesis via Oxidative Damage.

ABSTRACT: Bacterial cells develop mutations in the absence of cellular division through a process known as stationary-phase or stress-induced mutagenesis. This phenomenon has been studied in a few bacterial models, including Escherichia coli and Bacillus subtilis; however, the underlying mechanisms between these systems differ. For instance, RecA is not required for stationary-phase mutagenesis in B. subtilis like it is in E. coli. In B. subtilis, RecA is essential to the process of genetic transformation in the subpopulation of cells that become naturally competent in conditions of stress. Interestingly, the transcriptional regulator ComK, which controls the development of competence, does influence the accumulation of mutations in stationary phase in B. subtilis. Since recombination is not involve

SUBMITTER: Martin HA 

PROVIDER: S-EPMC7073564 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature