Prospective Investigation of Serum Metabolites, Coffee Drinking, Liver Cancer Incidence, and Liver Disease Mortality.

ABSTRACT:

Background

Coffee has been consistently associated with lower risk of liver cancer and chronic liver disease, suggesting that coffee affects mechanisms underlying disease development.

Methods

We measured serum metabolites using untargeted metabolomics in 1:1 matched nested case-control studies of liver cancer (n = 221 cases) and fatal liver disease (n = 242 cases) in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention cohort (n = 29 133). Associations between baseline coffee drinking and metabolites were identified using linear regression; conditional logistic regression models were used to identify associations with subsequent outcomes.

Results

Overall, 21 metabolites were associated with coffee drinking and also each subsequent endpoint; nine metabolites and trigo

SUBMITTER: Loftfield E 

PROVIDER: S-EPMC7073908 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature