Comparative Validation of Breast Cancer Risk Prediction Models and Projections for Future Risk Stratification.

ABSTRACT:

Background

External validation of risk models is critical for risk-stratified breast cancer prevention. We used the Individualized Coherent Absolute Risk Estimation (iCARE) as a flexible tool for risk model development and comparative model validation and to make projections for population risk stratification.

Methods

Performance of two recently developed models, one based on the Breast and Prostate Cancer Cohort Consortium analysis (iCARE-BPC3) and another based on a literature review (iCARE-Lit), were compared with two established models (Breast Cancer Risk Assessment Tool and International Breast Cancer Intervention Study Model) based on classical risk factors in a UK-based cohort of 64 874 white non-Hispanic women (863 patients) age 35-74 years. Risk projections in a tar

SUBMITTER: Pal Choudhury P 

PROVIDER: S-EPMC7073933 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature