Whole Genome Sequencing Indicates Heterogeneity of Hyperostotic Disorders in Dogs.

ABSTRACT: Craniomandibular osteopathy (CMO) and calvarial hyperostotic syndrome (CHS) are proliferative, non-neoplastic disorders affecting the skull bones in young dogs. Different forms of these hyperostotic disorders have been described in many dog breeds. However, an incompletely dominant causative variant for CMO affecting splicing of SLC37A2 has been reported so far only in three Terrier breeds. The purpose of this study was to identify further possible causative genetic variants associated with CHS in an American Staffordshire Terrier, as well as CMO in seven affected dogs of different breeds. We investigated their whole-genome sequences (WGS) and filtered variants using 584 unrelated genomes, which revealed no variants shared across all affected dogs. However, filtering for private var

SUBMITTER: Letko A 

PROVIDER: S-EPMC7074049 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature