Urinary Excretion of N¹-methyl-2-pyridone-5-carboxamide and N¹-methylnicotinamide in Renal Transplant Recipients and Donors.

ABSTRACT: N¹-methylnicotinamide (N¹-MN) and N¹-methyl-2-pyridone-5-carboxamide (2Py) are successive end products of NAD⁺ catabolism. N¹-MN excretion in 24-h urine is the established biomarker of niacin nutritional status, and recently shown to be reduced in renal transplant recipients (RTR). However, it is unclear whether 2Py excretion is increased in this population, and, if so, whether a shift in excretion of N¹-MN to 2Py can be attributed to kidney function. Hence, we assessed the 24-h urinary excretion of 2Py and N¹-MN in RTR and kidney donors before and after kidney donation, and investigated associations of the urinary ratio of 2Py to N¹-MN (2Py/N

SUBMITTER: Deen CPJ 

PROVIDER: S-EPMC7074074 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature