Opposite Roles of BAP1 in Overall Survival of Uveal Melanoma and Cutaneous Melanoma.

ABSTRACT:

Background

BRCA1-Associated Protein 1 (BAP1) germline mutations predispose individuals to cancers, including uveal melanoma (UM) and cutaneous melanoma (CM). BAP1 loss is common in UM and is associated with a worse prognosis. BAP1 loss is rare in CM and the outcome is unclear.

Methods

UM and CM data was retrieved from The Cancer Genome Atlas (TCGA) database. Cox regression model was performed to examine whether BAP1 mRNA levels or copy number variations were associated with overall survival (OS).

Results

BAP1-low mRNA predicted a poor OS in UM (HR = 9.57, 95% CI: 2.82, 32.5) but a contrasting better OS in CM (HR = 0.73, 95% CI: 0.56, 0.95). These results remained unchanged after adjusting for sex, age, and stage in UM and CM, or after adjusting for ulceration or Bresl

SUBMITTER: Liu-Smith F 

PROVIDER: S-EPMC7074098 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature