Alternative Splicing Events as Indicators for the Prognosis of Uveal Melanoma.

ABSTRACT: Growing evidence has revealed that abnormal alternative splicing (AS) events are closely related to carcinogenic processes. However, the comprehensive study on the prognostic value of splicing events involved in uveal melanoma (UM) is still lacking. Therefore, splicing data of 80 UM patients were obtained from the Cancer Genome Atlas (TCGA) SpliceSeq and RNA sequence data of UM and patient clinical features were downloaded from the Cancer Genome Atlas (TCGA) database to identify survival related splicing events in UM. As a result, a total of 37996 AS events of 17911 genes in UM were detected, among which 5299 AS events of 3529 genes were significantly associated with UM patients' survival. Functional enrichment analysis revealed that this survival related splicing genes are corelated with

SUBMITTER: Wan Q 

PROVIDER: S-EPMC7074237 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature