A Novel Proposal of Salivary Lymphocyte Detection and Phenotyping in Patients Affected by Sjogren's Syndrome.

ABSTRACT: A preliminary evaluation of the parotid secretion cellular composition in patients with Sjogren's Syndrome (SS) and a diagnostic accuracy assessment of salivary lymphocyte detection and immunophenotyping in Sjogren's Syndrome diagnosis and prognosis were performed. The study included 40 consecutive patients, aged 19-60 years, with parenchymal sialadenitis associated with Sjogren's Syndrome, and 20 healthy donors. The exclusion criteria were exacerbation of sialadenitis, chronic infections, malignant neoplasms, and lymphoproliferative diseases. The standard diagnostic tests were minor salivary gland biopsy and parotid sialography. Immunophenotyping of parotid secretion lymphocytes was performed by multicolor flow cytometry. Lymphocytes were detectable in parotid secretion of patients affect

SUBMITTER: Selifanova E 

PROVIDER: S-EPMC7074317 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature