Prognostic Value and Potential Regulatory Mechanism of Alternative Splicing in Geriatric Breast Cancer.

ABSTRACT: Breast cancer has the highest mortality and morbidity among women, especially in elderly women over 60 years old. Abnormal alternative splicing (AS) events are associated with the occurrence and development of geriatric breast cancer (GBC), yet strong evidence is lacking for the prognostic value of AS in GBC and the regulatory network of AS in GBC, which may highlight the mechanism through which AS contributes to GBC. In the present study, we obtained splicing event information (SpliceSeq) and clinical information for GBC from The Cancer Genome Atlas, and we constructed a GBC prognosis model based on AS events to predict the survival outcomes of GBC. Kaplan-Meier analysis was conducted to evaluate the predictive accuracy among different molecular subtypes of GBC. We conducted enrichment an

SUBMITTER: Li X 

PROVIDER: S-EPMC7074345 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature