Haploinsufficiency of Casitas B-Lineage Lymphoma Augments the Progression of Colon Cancer in the Background of Adenomatous Polyposis Coli Inactivation.

ABSTRACT: Casitas B-lineage lymphoma (c-Cbl) is a recently identified ubiquitin ligase of nuclear β-catenin and a suppressor of colorectal cancer (CRC) growth in cell culture and mouse tumor xenografts. We hypothesized that reduction in c-Cbl in colonic epithelium is likely to increase the levels of nuclear β-catenin in the intestinal crypt, augmenting CRC tumorigenesis in an adenomatous polyposis coli (APC^Δ14/+) mouse model. Haploinsufficient c-Cbl mice (APC^Δ14/+ c-Cbl^+/-) displayed a significant (threefold) increase in atypical hyperplasia and adenocarcinomas in the small and large intestines; however, no differences were noted in the adenoma frequency. In contrast to the APC^Δ14/+ c-Cbl^+/+ mice, APC^Δ14/+ c-Cbl^+/- crypts s

SUBMITTER: Richards S 

PROVIDER: S-EPMC7074366 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature