Investigating the Antiparasitic Potential of the Marine Sesquiterpene Avarone, Its Reduced form Avarol, and the Novel Semisynthetic Thiazinoquinone Analogue Thiazoavarone.

ABSTRACT: The chemical analysis of the sponge Dysideaavara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal agent, we converted the quinone avarone into the thiazinoquinone derivative thiazoavarone. The semisynthetic compound, as well as the natural metabolites avarone and avarol, were pharmacologically investigated in order to assess their antiparasitic properties against sexual and asexual stages of Plasmodiumfalciparum, larval and adult developmental stages of Schistosomamansoni (eggs included), and also against promastigotes and amastigotes of Leishmaniainfantum and Leishmaniatropica. Furthermore, in depth computational studies including dens

SUBMITTER: Imperatore C 

PROVIDER: S-EPMC7074381 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature