The Marine Seagrass Halophila stipulacea as a Source of Bioactive Metabolites against Obesity and Biofouling.

ABSTRACT: Marine organisms, including seagrasses, are important sources of biologically active molecules for the treatment of human diseases. In this study, organic extracts of the marine seagrass Halophila stipulacea obtained by different polarities from leaves (L) and stems (S) (hexane [HL, HS], ethyl acetate [EL, ES], and methanol [ML, MS]) were tested for different bioactivities. The screening comprehended the cytotoxicity activity against cancer cell lines grown as a monolayer culture or as multicellular spheroids (cancer), glucose uptake in cells (diabetes), reduction of lipid content in fatty acid-overloaded liver cells (steatosis), and lipid-reducing activity in zebrafish larvae (obesity), as well as the antifouling activity against marine bacteria (microfouling) and mussel larval settlement

SUBMITTER: Bel Mabrouk S 

PROVIDER: S-EPMC7074557 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature