Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation.

ABSTRACT:

Background

Endocrine-disrupting chemicals (EDCs) are environmental chemicals/toxicants that humans are exposed to, interfering with the action of multiple hormones. Bisphenol A (BPA) is classified as an EDC with xenoestrogenic activity with potentially adverse effects in reproduction. Currently, a significant knowledge gap remains regarding the complete spectrum of BPA-induced effects on the human placenta. As such, the present study examined the effects of physiologically relevant doses of BPA in vitro.

Methods

qRT-PCR, Western blotting, immunofluorescence, ELISA, microarray analyses, and bioinformatics have been employed to study the effects of BPA using nonsyncytialised (non-ST) and syncytialised (ST) BeWo cells.

Results

Treatment with 3 nM BPA led to an increase i

SUBMITTER: de Aguiar Greca SC 

PROVIDER: S-EPMC7074564 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature