Quantitative parametric maps of O-(2-[¹⁸F]fluoroethyl)-L-tyrosine kinetics in diffuse glioma.

ABSTRACT: Quantitative parametric images of O-(2-[¹⁸F]fluoroethyl)-L-tyrosine kinetics in diffuse gliomas could be used to improve glioma grading, tumour delineation or the assessment of the uptake distribution of this positron emission tomography tracer. In this study, several parametric images and tumour-to-normal maps were compared in terms of accuracy of region averages (when compared to results from nonlinear regression of a reversible two-tissue compartment plasma input model) and image noise using 90 min of dynamic scan data acquired in seven patients with diffuse glioma. We included plasma input methods (the basis function implementation of the single-tissue compartment model, spectral analysis and Logan graphical analysis) and reference tissue methods (basis function implementati

SUBMITTER: Koopman T 

PROVIDER: S-EPMC7074601 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature