Eu-Doped Citrate-Coated Carbonated Apatite Luminescent Nanoprobes for Drug Delivery.

ABSTRACT: In the field of Nanomedicine, there is an increasing demand for new inorganic nanophosphors with low cytotoxicity and efficient loading-release ability of drugs for applications in bioimaging and drug delivery. This work assesses the potentiality of matured Eu-doped citrate-coated carbonated apatite nanoparticles to be used as theranostic platforms, for bioimaging, as luminescent nanoprobes, and for drug delivery applications, using Doxorubicin as a model drug. The drug adsorption isotherm fits the Langmuir-Freundlich (LF) model, showing that the Eu:cit-cAp nanoparticles can carry a maximum of 0.29 ± 0.02 mg Doxo mg Eu:cit-cAp^-1 (Q_max). The affinity constant K_FL for this binding is 44 ± 2 mL mg^-1, and the cooperativity coefficient r is 6 ±

SUBMITTER: Jabalera Y 

PROVIDER: S-EPMC7074876 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature