Hypothyroidism and Kidney Function: A Mendelian Randomization Study.

ABSTRACT: Background: Uncertainty in the mechanism and directionality of observational associations between thyroid function and kidney function may be addressed by genetic analysis with an instrumental variable method termed bidirectional Mendelian randomization (MR). Methods: In the Women's Genome Health Study (WGHS), observational associations between thyroid measures and kidney function were evaluated. Genetic instruments for MR were from recent genome-wide association studies (GWAS) of hypothyroidism, thyrotropin (TSH), and free thyroxine (fT4) concentrations within the reference range, thyroid peroxidase antibodies (TPOAb), estimated glomerular filtration rate from creatinine (eGFR_crea), eGFR from cystatin C (eGFR_cys), and chronic kidney diseas

SUBMITTER: Ellervik C 

PROVIDER: S-EPMC7074918 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature