DTD: An R Package for Digital Tissue Deconvolution.

ABSTRACT: Digital tissue deconvolution (DTD) estimates the cellular composition of a tissue from its bulk gene-expression profile. For this, DTD approximates the bulk as a mixture of cell-specific expression profiles. Different tissues have different cellular compositions, with cells in different activation states, and embedded in different environments. Consequently, DTD can profit from tailoring the deconvolution model to a specific tissue context.

SUBMITTER: Schon M 

PROVIDER: S-EPMC7074920 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature