Translating traditional herbal formulas into modern drugs: a network-based analysis of Xiaoyao decoction.

ABSTRACT:

Background

Traditional Chinese medicine (TCM) encompasses numerous herbal formulas which play critical therapeutic roles through "multi-components, multi-targets and multi-pathways" mechanisms. Exploring the interaction among these mechanisms can certainly help to depict the core therapeutic function of herbal formulas. Xiaoyao decoction (XYD) is one of the most well-known traditional Chinese medicine formulas which has been widely applied to treat various diseases. In this study, taking XYD as an example, we proposed a network pharmacology-based method to identify the main therapeutic targets of this herbal concoctions.

Methods

Chemical data of XYD were retrieved from the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), Traditional Chinese Medicines Integ

SUBMITTER: Zhang D 

PROVIDER: S-EPMC7075005 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature