Calcineurin signaling pathway influences Aspergillus niger biofilm formation by affecting hydrophobicity and cell wall integrity.

ABSTRACT:

Background

Biofilms, as a kind of fixed-cell community, can greatly improve industrial fermentation efficiency in immobilized fermentation, but the regulation process is still unclear, which restricts their application. Ca²⁺ was reported to be a key factor affecting biofilm formation. However, the effect of Ca²⁺ on biofilm structure and microbiology was yet only studied in bacteria. How Ca²⁺-mediated calcineurin signaling pathway (CSP) alters biofilm formation in bacteria and fungi has rarely been reported. On this basis, we investigated the regulation of CSP on the formation of biofilm in Aspergillus niger.

Results

Deletion of the key genes MidA, CchA, CrzA or CnaA in the CSP lowered the Ca²⁺ con

SUBMITTER: Liu L 

PROVIDER: S-EPMC7075038 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature