Influences of Nanoparticles Characteristics on the Cellular Responses: The Example of Iron Oxide and Macrophages.

ABSTRACT: Iron oxide nanoparticles/microparticles are widely present in a variety of environments, e.g., as a byproduct of steel and iron degradation, as, for example, in railway brakes (e.g., metro station) or in welding fumes. As all particulate material, these metallic nanoparticles are taken up by macrophages, a cell type playing a key role in the innate immune response, including pathogen removal phagocytosis, secretion of free radical species such as nitric oxide or by controlling inflammation via cytokine release. In this paper, we evaluated how macrophages functions were altered by two iron based particles of different size (100 nm and 20 nm). We showed that at high, but subtoxic concentrations (1 mg/mL, large nanoparticles induced stronger perturbations in macrophages functions such as phag

SUBMITTER: Dalzon B 

PROVIDER: S-EPMC7075185 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature