Nanomedicines to Deliver mRNA: State of the Art and Future Perspectives.

ABSTRACT: The use of messenger RNA (mRNA) in gene therapy is increasing in recent years, due to its unique features compared to plasmid DNA: Transient expression, no need to enter into the nucleus and no risk of insertional mutagenesis. Nevertheless, the clinical application of mRNA as a therapeutic tool is limited by its instability and ability to activate immune responses; hence, mRNA chemical modifications together with the design of suitable vehicles result essential. This manuscript includes a revision of the strategies employed to enhance in vitro transcribed (IVT) mRNA functionality and efficacy, including the optimization of its stability and translational efficiency, as well as the regulation of its immunostimulatory properties. An overview of the nanosystems designed to protect the mRNA an

SUBMITTER: Gomez-Aguado I 

PROVIDER: S-EPMC7075285 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature