Clinical quantification of the integrin αvβ6 by [¹⁸F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study).

ABSTRACT:

Purpose

The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study sought to quantify expression of αvβ6 in the lungs of healthy humans and subjects with pulmonary fibrosis using the αvβ6-selective [¹⁸F]FB-A20FMDV2 PET ligand.

Methods

[¹⁸F]FB-A20FMDV2 PET/CT scans were performed in healthy subjects and those with fibrotic lung disease. Standard uptake values (SUV) and volume of distribution (V_T) were used to quantify αvβ6 expression. In subjects with fibrotic lung disease, qualitative assessment of the relationship between αvβ6 expression and the distribution of fibrosis on high resolution computed tomography was conducted.

Results

A total of 1

SUBMITTER: Lukey PT 

PROVIDER: S-EPMC7075837 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature