PSA and VIM DBS efficiency in essential tremor depends on distance to the dentatorubrothalamic tract.

ABSTRACT:

Objective

To investigate the relation between deep brain stimulation (DBS) of the posterior-subthalamic-area (PSA) and the ventral-intermediate-nucleus (VIM) and the distance to the dentatorubrothalamic tract (DRTT) in essential tremor (ET).

Methods

Tremor rating scale (TRS) hemi-scores were analyzed in 13 ET patients, stimulated in both the VIM and the PSA in a randomized, crossover trial. Distances of PSA and VIM contacts to population-based DRTTs were calculated. The relationships between distance to DRTT and stimulation amplitude, as well as DBS efficiency (TRS improvement per amplitude) were investigated.

Results

PSA contacts were closer to the DRTT (p = 0.019) and led to a greater improvement in TRS hemi-scores (p = 0.005) than VIM contacts. Proximity to the DRT

SUBMITTER: Dembek TA 

PROVIDER: S-EPMC7076091 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature