Protein S-glutathionylation reactions as a global inhibitor of cell metabolism for the desensitization of hydrogen peroxide signals.

ABSTRACT: The pathogenesis of many human diseases has been attributed to the over production of reactive oxygen species (ROS), particularly superoxide (O₂^●-) and hydrogen peroxide (H₂O₂), by-products of metabolism that are generated by the premature reaction of electrons with molecular oxygen (O₂) before they reach complex IV of the respiratory chain. To date, there are 32 known ROS generators in mammalian cells, 16 of which reside inside mitochondria. Importantly, although these ROS are deleterious at high levels, controlled and temporary bursts in H₂O₂ production is beneficial to mammalian cells. Mammalian cells use sophisticated systems to take advantage of the second messaging properties of H₂O₂. T

SUBMITTER: Mailloux RJ 

PROVIDER: S-EPMC7076094 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature