TADCompare: An R Package for Differential and Temporal Analysis of Topologically Associated Domains.

ABSTRACT: Recent research using chromatin conformation capture technologies, such as Hi-C, has demonstrated the importance of topologically associated domains (TADs) and smaller chromatin loops, collectively referred hereafter as "interacting domains." Many such domains change during development or disease, and exhibit cell- and condition-specific differences. Quantification of the dynamic behavior of interacting domains will help to better understand genome regulation. Methods for comparing interacting domains between cells and conditions are highly limited. We developed TADCompare, a method for differential analysis of boundaries of interacting domains between two or more Hi-C datasets. TADCompare is based on a spectral clustering-derived measure called the eigenvector gap, which enables a loci-by

SUBMITTER: Cresswell KG 

PROVIDER: S-EPMC7076128 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature