Galectin 3-binding protein suppresses amyloid-β production by modulating β-cleavage of amyloid precursor protein.

ABSTRACT: Alzheimer's disease (AD) is the most common type of dementia, and its pathogenesis is associated with accumulation of β-amyloid (Aβ) peptides. Aβ is produced from amyloid precursor protein (APP) that is sequentially cleaved by β- and γ-secretases. Therefore, APP processing has been a target in therapeutic strategies for managing AD; however, no effective treatment of AD patients is currently available. Here, to identify endogenous factors that modulate Aβ production, we performed a gene microarray-based transcriptome analysis of neuronal cells derived from human induced pluripotent stem cells, because Aβ production in these cells changes during neuronal differentiation. We found that expression of the glycophosphatidylinositol-specific phospholipase D1 (GPLD1) gene is associated wit

SUBMITTER: Seki T 

PROVIDER: S-EPMC7076203 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature