The nonreceptor tyrosine kinase SYK drives caspase-8/NLRP3 inflammasome-mediated autoinflammatory osteomyelitis.

ABSTRACT: Chronic recurrent multifocal osteomyelitis (CRMO) in humans can be modeled in Pstpip2^cmo mice, which carry a missense mutation in the proline-serine-threonine phosphatase-interacting protein 2 (Pstpip2) gene. As cmo disease in mice, the experimental model analogous to human CRMO, is mediated specifically by IL-1β and not by IL-1α, delineating the molecular pathways contributing to pathogenic IL-1β production is crucial to developing targeted therapies. In particular, our earlier findings support redundant roles of NLR family pyrin domain-containing 3 (NLRP3) and caspase-1 with caspase-8 in instigating cmo However, the signaling components upstream of caspase-8 and pro-IL-1β cleavage in Pstpip2^cmo mice are not well-understood. Therefo

SUBMITTER: Dasari TK 

PROVIDER: S-EPMC7076204 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature