MiR-331-3p Suppresses Cell Proliferation in TNBC Cells by Downregulating NRP2.

ABSTRACT: PURPOSE:Triple-negative breast cancer is characterized by fast progression with high possible for metastasis and poor survival. Dysfunction of microRNAs plays an important role in the initiation and progression of cancer. Our previous microRNA-seq data indicated the downregulation of miR-331-3p in triple-negative breast cancer tissues compared with that of the noncancer tissues. However, the function of miR-331-3p in triple-negative breast cancer remains largely unknown. Herein, the involvement of miR-331-3p in triple-negative breast cancer was investigated and the therapeutic potential of miR-331-3p was also explored. METHODS:Real-time quantitative polymerase chain reaction was performed to detect the expression of miR-331-3p in triple-negative breast cancer tissues and cell lines. The ce

SUBMITTER: Zhao M 

PROVIDER: S-EPMC7076578 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature