Sphingomyelin-Based Nanosystems (SNs) for the Development of Anticancer miRNA Therapeutics.

ABSTRACT: Gene replacement therapy with oncosuppressor microRNAs (miRNAs) is a promising alternative to interfere with cancer progression. However, miRNAs are highly inefficient in a biological environment, hampering a successful translation to clinics. Nanotechnology can tackle this drawback by providing delivery systems able to efficiently deliver them to cancer cells. Thus, the objective of this work was to develop biocompatible nanosystems based on sphingomyelin (SM) for the intracellular delivery of miRNAs to colorectal cancer cells. We pursued two different approaches to select the most appropriate composition for miRNA delivery. On the one hand, we prepared sphingomyelin-based nanosystems (SNs) that incorporate the cationic lipid stearylamine (ST) to support the association of miRNA by the es

SUBMITTER: Nagachinta S 

PROVIDER: S-EPMC7076701 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature