Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.

ABSTRACT:

Background

Recent studies indicated that seeded fibril formation and toxicity of α-synuclein (α-syn) play a main role in the pathogenesis of certain diseases including Parkinson's disease (PD), multiple system atrophy, and dementia with Lewy bodies. Therefore, examination of compounds that abolish the process of seeding is considered a key step towards therapy of several synucleinopathies.

Methods

Using biophysical, biochemical and cell-culture-based assays, assessment of eleven compounds, extracted from Chinese medicinal herbs, was performed in this study for their effect on α-syn fibril formation and toxicity caused by the seeding process.

Results

Salvianolic acid B and dihydromyricetin were the two compounds that strongly inhibited the fibril growth and neurotoxici

SUBMITTER: Ardah MT 

PROVIDER: S-EPMC7076823 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature