Study on the mechanisms of compound Kushen injection for the treatment of gastric cancer based on network pharmacology.

ABSTRACT:

Background

As an effective prescription for gastric cancer (GC), Compound Kushen Injection (CKI) has been widely used even though few molecular mechanism analyses have been carried out.

Methods

In this study, we identified 16 active ingredients and 60 GC target proteins. Then, we established a compound-predicted target network and a GC target protein-protein interaction (PPI) network by Cytoscape 3.5.1 and systematically analyzed the potential targets of CKI for the treatment of GC. Finally, molecular docking was applied to verify the key targets. In addition, we analyzed the mechanism of action of the predicted targets by Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses.

Results

The results showed that the potential targets, including CC

SUBMITTER: Zhou W 

PROVIDER: S-EPMC7076865 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature