A systematic analysis of natural α-glucosidase inhibitors from flavonoids of Radix scutellariae using ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology.

ABSTRACT:

Background

Flavonoids from plant medicines are supposed to be viable alternatives for the treatment of type 2 diabetes (T2D) as less toxicity and side effects. Radix scutellariae (RS) is a widely used traditional medicine in Asia. It has shown great potential in the research of T2D. However, the pharmacological actions remain obscured due to the complex chemical nature of plant medicines.

Methods

In the present study, a systematic method combining ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology was developed to screen α-glucosidase inhibitors from flavonoids of RS, and explore the underlying mechanism for the treatment of T2D.

Results

The n-butanol part of ethanol extract from RS showed a strong α-glucosidase inhibition activity (90.55%, IC₅₀

SUBMITTER: Wang L 

PROVIDER: S-EPMC7076893 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature