Six-Month Randomized, Multicenter Trial of Closed-Loop Control in Type 1 Diabetes.

ABSTRACT:

Background

Closed-loop systems that automate insulin delivery may improve glycemic outcomes in patients with type 1 diabetes.

Methods

In this 6-month randomized, multicenter trial, patients with type 1 diabetes were assigned in a 2:1 ratio to receive treatment with a closed-loop system (closed-loop group) or a sensor-augmented pump (control group). The primary outcome was the percentage of time that the blood glucose level was within the target range of 70 to 180 mg per deciliter (3.9 to 10.0 mmol per liter), as measured by continuous glucose monitoring.

Results

A total of 168 patients underwent randomization; 112 were assigned to the closed-loop group, and 56 were assigned to the control group. The age range of the patients was 14 to 71 years, and the glycated hemogl

SUBMITTER: Brown SA 

PROVIDER: S-EPMC7076915 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature