Characterization of antibiotic resistance and host-microbiome interactions in the human upper respiratory tract during influenza infection.

ABSTRACT:

Background

The abundance and diversity of antibiotic resistance genes (ARGs) in the human respiratory microbiome remain poorly characterized. In the context of influenza virus infection, interactions between the virus, the host, and resident bacteria with pathogenic potential are known to complicate and worsen disease, resulting in coinfection and increased morbidity and mortality of infected individuals. When pathogenic bacteria acquire antibiotic resistance, they are more difficult to treat and of global health concern. Characterization of ARG expression in the upper respiratory tract could help better understand the role antibiotic resistance plays in the pathogenesis of influenza-associated bacterial secondary infection.

Results

Thirty-seven individuals participating in

SUBMITTER: Zhang L 

PROVIDER: S-EPMC7076942 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature