The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure.

ABSTRACT:

Background

Allele-specific DNA methylation (ASM) describes genomic loci that maintain CpG methylation at only one inherited allele rather than having coordinated methylation across both alleles. The most prominent of these regions are germline ASMs (gASMs) that control the expression of imprinted genes in a parent of origin-dependent manner and are associated with disease. However, our recent report reveals numerous ASMs at non-imprinted genes. These non-germline ASMs are dependent on DNA methyltransferase 1 (DNMT1) and strikingly show the feature of random, switchable monoallelic methylation patterns in the mouse genome. The significance of these ASMs to human health has not been explored. Due to their shared allelicity with gASMs, herein, we propose that non-traditional ASMs are

SUBMITTER: Freeman DM 

PROVIDER: S-EPMC7076959 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature