HOXB4 promotes the malignant progression of ovarian cancer via DHDDS.

ABSTRACT: BACKGROUND:Homeobox B4 (HOXB4) is correlated with poor prognosis of various cancer types. However, how HOXB4 promotes ovarian cancer (OV) progression remains unclear. METHODS:The Cancer Genome Atlas (TCGA) database indicated that a high level of HOXB4 in OV was correlated with poor prognosis. The biological functions of HOXB4 were confirmed by colony formation, migration, and invasion assays. The effect of HOXB4 on the expression of EMT cell markers was determined. The transcriptional target of HOXB4 was DHDDS, which was detected by a ChIP assay. A xenograft tumor model was generated in nude mice to detect the role of HOXB4 in tumor proliferation and metastasis. RESULTS:The results showed that HOXB4 protein levels were higher in OV tissues than in normal tissues and correlated with poor pr

SUBMITTER: Li N 

PROVIDER: S-EPMC7077141 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature