The Heat Shock Response in the Western Honey Bee (Apis mellifera) is Antiviral.

ABSTRACT: Honey bees (Apismellifera) are an agriculturally important pollinator species that live in easily managed social groups (i.e., colonies). Unfortunately, annual losses of honey bee colonies in many parts of the world have reached unsustainable levels. Multiple abiotic and biotic stressors, including viruses, are associated with individual honey bee and colony mortality. Honey bees have evolved several antiviral defense mechanisms including conserved immune pathways (e.g., Toll, Imd, JAK/STAT) and dsRNA-triggered responses including RNA interference and a non-sequence specific dsRNA-mediated response. In addition, transcriptome analyses of virus-infected honey bees implicate an antiviral role of stress response pathways, including the heat shock response. Herein, we demonstrate

SUBMITTER: McMenamin AJ 

PROVIDER: S-EPMC7077298 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature