A new strategy for the in vitro selection of stapled peptide inhibitors by mRNA display.

ABSTRACT: Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.

SUBMITTER: Iqbal ES 

PROVIDER: S-EPMC7077329 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature