Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F.

ABSTRACT: Rocaglates are a diverse family of biologically active molecules that have gained tremendous interest in recent years due to their promising activities in pre-clinical cancer studies. As a result, this family of compounds has been significantly expanded through the development of efficient synthetic schemes. However, it is unknown whether all of the members of the rocaglate family act through similar mechanisms of action. Here, we present a comprehensive study comparing the biological activities of >200 rocaglates to better understand how the presence of different chemical entities influences their biological activities. Through this, we find that most rocaglates preferentially repress the translation of mRNAs containing purine-rich 5' leaders, but certain rocaglates lack this bias in tran

SUBMITTER: Chu J 

PROVIDER: S-EPMC7077502 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature