SST5 expression and USP8 mutation in functioning and silent corticotroph pituitary tumors.

ABSTRACT: Somatostatin receptor type 5 (SST5) is inconsistently expressed by corticotroph tumors, with higher expression found in corticotropinomas having ubiquitin-specific protease 8 (USP8) mutations. Aims were to study the correlation between characteristics of corticotropinomas and SST5 expression/USP8 mutation status and to describe the response to pasireotide in 5 patients. Retrospective cohort study. Clinico-biochemical, radiological and pathological data of 62 patients, operated for a functioning or silent corticotropinoma between 2013 and 2017, were collected. SST5 expression was measured by immunohistochemistry (clone UMB-4, Abcam, IRS>1 being considered positive) and Sanger sequencing was performed on 50 tumors to screen for USP8 mutations. SST5 expression was positive in 26/62 pituitary

SUBMITTER: Castellnou S 

PROVIDER: S-EPMC7077525 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature