Nitrated meat products are associated with mania in humans and altered behavior and brain gene expression in rats.

ABSTRACT: Mania is a serious neuropsychiatric condition associated with significant morbidity and mortality. Previous studies have suggested that environmental exposures can contribute to mania pathogenesis. We measured dietary exposures in a cohort of individuals with mania and other psychiatric disorders as well as in control individuals without a psychiatric disorder. We found that a history of eating nitrated dry cured meat but not other meat or fish products was strongly and independently associated with current mania (adjusted odds ratio 3.49, 95% confidence interval (CI) 2.24-5.45, p < 8.97 × 10^-8). Lower odds of association were found between eating nitrated dry cured meat and other psychiatric disorders. We further found that the feeding of meat preparations with added nitrate to

SUBMITTER: Khambadkone SG 

PROVIDER: S-EPMC7077736 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature