Myocardial dysfunction in long-term breast cancer survivors treated at ages 40-50 years.

ABSTRACT:

Aims

Anthracyclines increase heart failure (HF) risk, but the long-term prevalence of myocardial dysfunction in young breast cancer (BC) survivors is unknown. Early measures of left ventricular myocardial dysfunction are needed to identify BC patients at risk of symptomatic HF.

Methods and results

Within an established cohort, we studied markers for myocardial dysfunction among 569 women, who were 5-7 years (n = 277) or 10-12 years (n = 292) after BC treatment at ages 40-50 years. Left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) were assessed by echocardiography. N-terminal pro-brain natriuretic peptide (NT-proBNP) was measured in serum. Associations between patient-related and treatment-related risk factors and myocardial dysfunction were evalu

SUBMITTER: Jacobse JN 

PROVIDER: S-EPMC7077738 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature