Response of FDG avid pelvic bone marrow to concurrent chemoradiation for anal cancer.

ABSTRACT:

Background and purpose

To determine if suppression of active bone marrow, as defined on FDG PETCT, is seen in on-treatment imaging of anal cancer patients receiving concurrent chemoradiation.

Methods and materials

Scans from 26 patients participating in the ART trial (full title: Anal squamous cell carcinoma: Investigation of functional imaging during chemoRadioTherapy), a single center observational study with FDG PETCT prior to radiotherapy and at fraction 8-10 of concurrent chemoradiation were analysed. Active bone marrow was contoured in both the pelvis and un-irradiated thoracic spine. SUV and volume of active bone marrow after 8-10 fractions of treatment were compared to baseline. Dose metrics to pelvic active bone marrow were extracted and compared to reduction in SUV

SUBMITTER: Robinson M 

PROVIDER: S-EPMC7077746 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature